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Nanex exchange published a shutdown announcement in April 2019. This announcement was later deleted from the company’s blog on Medium.
Trade.io (currently (TIOmarkets) is a centralized trading platform. In October, 2019, the Trade.io exchange suspended its operation and rebranded in TIOmarkets to be able to provide more markets, such as forex, shares, indexes, metals and cryptos. 
EtherFlyer is a decentralized exchange started in 2018. It maintains trading with pairs structured against BTC and ETH.